Part 1 mentioned what niacin is and why it is wanted. Right here is Part 2, where Alex Leaf and I cope with blood checks, food and supplements!
- How much do we’d like? The RDA has some shortcomings, including the requirement of girls less than men, when all the evidence exhibits that ladies want * extra * than males. 19659004] How niacin in your espresso, seeds and grains is all locked and obtainable, and learn how to launch it with proper preparation. Do you drink mild roasted or darkish roasts? You’ll be able to hate or love this episode… or you possibly can just change espresso.
- Ought to excessive doses of niacin be taken to decrease ldl cholesterol? Alex has a concept on how we will do it with out getting diabetes. 19
- High dose niacin may cause liver failure and can kill lab mice. But Alex and I know how to cope with this drawback!
- NAD-enhancing components are new pricey to the growing older business. But ought to we take nicotinamide riboside (NR), a nicotinamide mononucleotide (NMN), or ought to we take all of the burning of the entire body? We talk about the promises and issues of those approaches.
- Why do you have to mix glycine with niacin and trimethylglycine (TMG) with everyone.
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Depart a remark
00:38 Cliff Notes
01:35 Part 1
15:32 Niacin Area Marks
17:32 Methylated Metabolites of Niacin in the Urine as a Sign of Niacin
19:05 Warning of using methylated metabolites of niacin in urine as an indication of the state of niacin
20:16 NAD (H) / NADP (H) ratio of Erythrocytes as a sign of the state of niacin
22:55 Maintaining the number of niacin as a sign of the state of niacin
28:34 Criticism of how Niacin RDA
40:12 How does protein consumption have an effect on the eating regimen of prefabricated niacin  42:48 Estrogen regulates the synthesis of niacin from tryptophan
43:35 Notably in males, niacin synthesis from tryptophan can solely be a approach to purify excess tryptophan.
45:31 Basic Discussion on Protein Necessities
49:46 How Totally different Food Remedy Modes, reminiscent of Nexamalization, fermentation and germination, improve niacin bioavailability
52:51 Niacin in Coffee
53:52 Niacin in nutritional yeast
54:16 Niacin sources of food, divided into five levels
59:57 Niacins in herbs and spices, together with spirulina
01:03:46 The share of microbiome in niacin has not been properly studied.
01:04:56 The place Do We Look For Niacin Deficiency Detection
1:05:38 The danger elements for niacin deficiency are Hartnup's disease, the Moonworm, intestinal Mala. Bsorption, Carcinoid tumors, Certain medicine, Alcoholism, HIV / AIDS and iron, riboflavin and B6 deficiencies
01:09:52 Suboptimal Niacin Danger Elements Embrace Uncooked Food regimen Entire Grains, Sugar-Fats Food plan, Low Non- collagen protein-containing food regimen, any cell injury and low ATP degree
01:14:42 How metformin and berberine might have an effect on the niacin state
01:17:28 Impact of leucine and muscle progress on niacin
01:19:54 Prevalence of inadequate consumption of niacin and niacin deficiency
01:24:00 Elements selling niacin toxicity
01:25:08 Use of nicotinic acid to profit blood lipids and scale back danger of coronary heart disease  01:31:14 Potential negative effects of nicotinic acid on blood lipid control ova t rinsing, liver injury and growing results.
01: 34:22 Mechanism of Excessive Dose Mechanism of Nicotinic Acid-Induced Insulin Resistance and its Reduction
01:48:01 Nicotine amide riboside insertion rodent research
01:50:58 Human research of nicotinamide riboside addition 19659012] 01:56:32 Why do rodent studies on nicotine amide riboside addition look more promising than human studies
02:04:16 What is the chance that somebody would get longevity by supplementing nicotinamide riboside?
02:05:15 or not Alex and Chris start supplementing niacin after learning this podcast
02:06:17 If somebody with hypercholesterolemia is considering taking nicotinic acid?
02:10:53 Is it necessary to take niacin with food?
Yvan-Charvet L, Kling J, Pagler T, Li H, Hubbard B, Fisher T, Sparrow CP, Taggart AK, Tall AR. Excessive density lipoprotein cholesterol and anti-inflammatory medicine with niacin or anacetrapib after remedy. Arterioscler Thromb Vasc Biol [Internet]. July 2010, 30 (7): 1430-1438. Out there at: http://dx.doi.org/10.1161/ATVBAHA.110.207142 PMCID: PMC2917780
Khera AV, Patel PJ, Reilly MP, Rader DJ. Including niacin to statin remedy improves high-density lipoprotein levels of cholesterol, but not performance. J Am Coll Cardiol [Internet]. 2013 November 12; 62 (20): 1909-1910. Out there at: http://dx.doi.org/10.1016/j.jacc.2013.07.025 PMID: 23933538
Kamanna VS, Ganji SH, Kashyap ML. Current advances within the metabolism of niacin and lipids. Curr Opin Lipidol [Internet]. June 2013, 24 (3): 239-245. Obtainable from: http://dx.doi.org/10.1097/MOL.0b013e3283613a68 PMID: 23619367
Garg A, Sharma A, Krishnamoorthy P, Garg J, Virmani D, Sharma T, Stefanini G, Kostis JB, Mukherjee D , Sikorskaya E. Position of Niacin in Present Medical Apply: Systematic Assessment. Am J Med. [Internet]. 2017 Feb. 130 (2): 173-187. Obtainable at: http://dx.doi.org/10.1016/j.amjmed.2016.07.038 PMID: 27793642
Wang W, Basinger A, Neese RA, Christiansen M, Hellerstein MK. Results of nicotinic acid on fatty acid kinetics, gasoline selection and glucose production pathways in ladies. Am J Physiol Endocrinol Metab [Internet]. July 2000, 279 (1): E50-9. Out there at: http://dx.doi.org/10.1152/ajpendo.2000.279.1.E50 PMID: 10893322
Goldie C, Taylor AJ, Nguyen P, McCoy C, Zhao XQ, Preiss D. Niacin Remedy And New Diabetes danger: meta-analysis of randomized managed research. Coronary heart [Internet]. February 2016 102 (three): 198–203. Obtainable from: http://dx.doi.org/10.1136/heartjnl-2015-308055 PMCID: PMC4752613
Maciejewski-Lenoir D, Richman JG, Hakak Y, Gaidarov I, Behan DP, Connolly DT. Langerhans cells release prostaglandin D2 in response to nicotinic acid. J Invest Dermatol [Internet]. December 2006, 126 (12): 2637-2646. Obtainable at: http://dx.doi.org/10.1038/sj.jid.5700586 PMID: 17008871
Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed Okay, Tunaru S, Wirth A, Bargains S. Nicotinic acid and monomethyl fumarate-induced redness comprise GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J Clin Invest [Internet]. August 2010, 120 (eight): 2910-2919. Out there at: http://dx.doi.org/10.1172/JCI42273 PMCID: PMC2912194
Dunbar RL, Gelfand JM. Purple: stimulation of niacin-related pores and skin toxicity. J Clin Invest [Internet]. August 2010, 120 (8): 2651-2655. Out there at: http://dx.doi.org/10.1172/JCI44098 PMCID: PMC2912206
Stern RH, Spence JD, Freeman DJ, Parbtani A. Rinse of Nicotinic Acid. Clin Pharmacol Ther. [Internet]. 1991 July, 50 (1): 66-70. Obtainable at: https://www.ncbi.nlm.nih.gov/pubmed/1855354 PMID: 1855354
Stern RH, Freeman D, Spence JD. Differences in time launch and metabolism of unmodified nicotinic acid: an evidence of the variations within the impact of hypolipidem? Metabolism [Internet]. August 1992, 41 (8): 879-881. Out there at: https://www.ncbi.nlm.nih.gov/pubmed/1640866 PMID: 1640866
Kourtzidis IA, Dolopikou CF, Tsiftsis AN, Margaritelis NV, Theodorou AA, Zervos IA, Tsantarliotou MP, Veskoukis AS, Vrabas IS, Paschalis V, Kyparos A, Nikolaidis MG. Addition of nicotinamide riboside regulates redox and power metabolism in rats: Effects on exercise performance. Exp Physiol [Internet]. October 2018, 103 (10): 1357-1366. Obtainable at: http://dx.doi.org/10.1113/EP086964 PMID: 30007015
Piepho RW. Pharmacokinetics of drugs and Pharmacodynamics, which have been shown to increase high-density lipoprotein ldl cholesterol. Am J Cardiol [Internet]. December 2000; 86 (12A): 35L-40L. Obtainable at: https://www.ncbi.nlm.nih.gov/pubmed/11374854 PMID: 11374854
Poddar SK, Sifat AE, Haque S, Nahid NA, Chowdhury S, Mehedi I. Nicotinamide Mononucleotide: Analysis on Versatile Research molecular therapeutic purposes. Biomolecules [Internet]. 2019, January 21, 9 (1). Out there at: http://dx.doi.org/10.3390/biom9010034 PMCID: PMC6359187
Fricker RA, Green EL, Jenkins SI, Griffin SM. Effect of nicotinamide on health and illnesses of the central nervous system. Int J Tryptophan Res. [Internet]. 2018 Might 21, 11: 1178646918776658. Out there at: http://dx.doi.org/10.1177/1178646918776658 PMCID: PMC5966847
Chi Y, Sauve AA. Nicotinamide riboside, a micro-nutrient for food, is vitamin B3 with effects on power metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care [Internet]. 2013 November, 16 (6): 657-661. Out there at: http://dx.doi.org/10.1097/MCO.0b013e32836510c0 PMID: 24071780
Dollerup OL, Christensen B, Svart M, Schmidt MS, Sulek Okay, Ringgaard S, Stødkilde-Jørgensen H, Møller N, Brenner C, Treebak JT, Jessen N. Randomized, placebo-controlled medical research of nicotinamide riboside in overweight men: safety, insulin sensitivity, and lipid mobilizing effect. Am J Clin Nutr [Internet]. 2018 August 1, 108 (2): 343-353. Obtainable at: http://dx.doi.org/10.1093/ajcn/nqy132 PMID: 29992272
Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR. The persistent addition of nicotinamide riboside is properly tolerated and raises NAD + in wholesome middle-aged and elderly adults. Nat Commun [Internet]. 2018 March 29, 9 (1): 1286. Obtainable at: http://dx.doi.org/10.1038/s41467-018-03421-7 PMCID: PMC5876407
Airhart SE, Shireman LM, Risler LJ, Anderson GD, Nagana Gowda GA, Raftery D, Tian R, Shen DD, Brien KD. Open-label, randomized research of the pharmacokinetics of nicotinamide riboside (NR) supplementation and its results on blood NAD + ranges in healthy volunteers. PLoS One [Internet]. December 2017 6; 12 (12): e0186459. Obtainable at: http://dx.doi.org/10.1371/journal.pone.0186459 PMCID: PMC5718430
Morgan JM, Capuzzi DM, Guyton JR. New long-acting niacin (Niaspan): efficacy, tolerability and security for hypercholesterolemia in patients. Am J Cardiol [Internet]. December 17, 1998; 82 (12A): 29U – 34U; conversation 39U – 41U. Obtainable at: https://www.ncbi.nlm.nih.gov/pubmed/9915660 PMID: 9915660
Keenan JM. Wax Matrix Extended Niacin vs. Inositol-Hexanicotinate: Comparability of "non-flush" bluein of blood matrix, prolonged launch niacin, and inositol hexanicotinate in subjects with delicate to average dyslipidemia. J Clin Lipidol [Internet]. 2013 Jan, 7 (1): 14-23. Obtainable at: http://dx.doi.org/10.1016/j.jacl.2012.10.004 PMID: 23351578
Soudijn W, van Wijngaarden I, Ijzerman AP. Subtypes of nicotinic acid receptor and their ligands. Med Res Rev [Internet]. Might 2007, 27 (3): 417-433. Obtainable at: http://dx.doi.org/10.1002/med.20102 PMID: 17238156
Ellinger P, Kader MM. Metabolism of nicotinamide in mammals. Biochem J [Internet]. , 1949; 44 (1): 77-87. Out there at: https://www.ncbi.nlm.nih.gov/pubmed/16748483 PMCID: PMC1274811
Stratford MR, Dennis MF, Hoskin P, Phillips H, Hodgkiss RJ, Rojas A. Pharmacokinetics of Nicotinamide in Humans: Impact on Abdomen inhibition, rectal, and oral administration and comparison with using saliva in monitoring drug. Br J Cancer [Internet]. July 1996, 74 (1): 16-21. Obtainable at: https://www.ncbi.nlm.nih.gov/pubmed/8679452 PMCID: PMC2074616
Dragovic J, Kim SH, Brown SL, Kim JH. Pharmacokinetics of nicotinamide in patients. Radiother Oncol [Internet]. 1995 Sep, 36 (3): 225-228. Out there from: https://www.ncbi.nlm.nih.gov/pubmed/8532910 PMID: 8532910
McKenney JM, Proctor JD, Harris S, Chinchili VM. Comparison of efficacy and toxic effects of long-acting and fast launch niacin in hypercholesterolemic patients. JAMA [Internet]. 1994 Mar 2, 271 (9): 672-677. Out there at: https://www.ncbi.nlm.nih.gov/pubmed/8309029 PMID: 8309029
Pieper AND. Understanding Niacin Preparations. I J Manag Care [Internet]. 2002 Sep, 8 (12 Suppl): S308-14. Out there at: https://www.ncbi.nlm.nih.gov/pubmed/12240702 PMID: 12240702
Wallace TC, McBurney M, Fulgoni VL 3. Adding a multi-vitamin / mineral additive to micronutrients in the USA, 2007-2010. J Am Coll Nutr [Internet]. 2014; 33 (2): 94-102. Obtainable at: http://dx.doi.org/10.1080/07315724.2013.846806 PMID: 24724766
Moreschi I, Bruzzone S, Nicholas RA, Fruscione F, Sturla L, Benvenuto F, Usai C, Meis S, Kassack MU , Zocchi E, De Flora A. Extrasellular NAD + is a human P2Y11 purinergic receptor agonist in human granulocytes. J. Biol. Chem. [Internet]. October 20, 2006; 281 (42): 31419-31429. Obtainable at: http://dx.doi.org/10.1074/jbc.M606625200 PMID: 16926152
Airhart SE, Shireman LM, Risler LJ, Anderson GD, Nagana Gowda GA, Raftery D, Tian R, Shen DD, O & # 39; Brien KD. Open-label, randomized research of the pharmacokinetics of nicotinamide riboside (NR) supplementation and its effects on blood NAD + ranges in wholesome volunteers. PLoS One [Internet]. journals.plos.org; December 2017 6; 12 (12): e0186459. Obtainable at: http://dx.doi.org/10.1371/journal.pone.0186459 PMCID: PMC5718430
Jacobson EL, Jacobson MK.  Tissue NAD as a biochemical measure of the state of niacin in humans. Strategies of enzymology [Internet]. Educational Press; 1997, pp. 221-230. Obtainable at: http://www.sciencedirect.com/science/article/pii/S0076687997801139  Jacobson EL, Jacobson MK. Biochemical technique for measuring the state of niacin in a organic pattern [Internet]. U.S. Patent. 6287796, 2001 [cited 2019 Feb 16]. Obtainable at: https://patentimages.storage.googleapis.com/19/41/2d/a1de97bc17d927/US6287796.pdf P.19659012] Fu CS, Swendex ME, Jacob RA, McKee RW. Biochemical markers for assessing the standing of niacin in young men: ranges of erythrocyte niacin coenzymes and plasma tryptophan. J Nutr [Internet]. educational.oup.com; 1989 December, 119 (12): 1949-1955. Out there at: http://dx.doi.org/10.1093/jn/119.12.1949 PMID: 2621487
Nutritional Values for Power, Carbohydrate, Fibers, Fatty Acids, Ldl cholesterol, Protein and Amino Acids: Well being and Drugs [Internet] . [cited 2019 Feb 16]. Obtainable at: http://www.nationalacademies.org/hmd/Reports/2002/Dietary-Reference-Investment-for-Energy-Carbohydrate-Fiber-Fat-Acids-Cholesterol-Protein-and-Amino-Acids.aspx  Dölle C, Skoge RH, MR Vanlinden, Ziegler M. NAD biosynthesis in humans – enzymes, metabolites and therapeutic features. Curr Prime Med Chem [Internet]. ingentaconnect.com; 2013; 13 (23): 2907-2917. Out there at: https://www.ncbi.nlm.nih.gov/pubmed/24171775 PMID: 24171775
Clegg KM. NICOTIN-HAPPE IN DIETARIAN WHEATEN PRODUCTS. Br J Nutr [Internet]. cambridge.org; in 1963; 17: 325-329. Out there at: https://www.ncbi.nlm.nih.gov/pubmed/14045335 PMID: 14045335
Adrian J, Frangne R. Synthesis and availability of niacin in roasted espresso. Adv Exp Med Biol [Internet]. Springer; 1991; 289: 49-59. Obtainable at: https://www.ncbi.nlm.nih.gov/pubmed/1897406 PMID: 1897406
Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa Okay, Silverman IM, Quinn WJ third, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. The disappearance of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle. Cell Metab [Internet]. August 9, 2016; 24 (2): 269-282. Obtainable at: http://dx.doi.org/10.1016/j.cmet.2016.07.005 PMCID: PMC4985182
Liu L, Su X, Quinn WJ third, Hui S, Krukenberg Okay, Frederick DW, Redpath P, Zhan L, Chellappa Okay, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD. Quantitative analysis of NAD synthesis degradation currents. Cell Metab [Internet]. 2018 Might 1, 27 (5): 1067-1080.e5. Out there at: http://dx.doi.org/10.1016/j.cmet.2018.03.018 PMCID: PMC5932087
Creeke PI, Dibari F, Cheung E, van den Briel T, Kyroussis E, Seal AJ. Blood NAD and NADP levels are usually not depressed in patients with medical pellagra. J Nutr [Internet]. educational.oup.com; September 2007, 137 (9): 2013–2017. Out there at: http://dx.doi.org/10.1093/jn/137.9.2013 PMID: 17709435
Strohm D, Bechthold A, Isik N, Leschik-Bonnet E, Heseker H. Revised Reference Thiamine (Vitamin B1 ), riboflavin (vitamin B2) and niacin. NFS Journal [Internet]. Elsevier; 2016 1 August 3: 20-24. Obtainable at: http://www.sciencedirect.com/science/article/pii/S2352364615300432  Pissios P. Nicotinamide N-Methyltransferase: Extra Than Vitamin B3 Purification Enzyme. Development Endocrinol Metab [Internet]. Might 2017, 28 (5): 340-353. Obtainable at: http://dx.doi.org/10.1016/j.tem.2017.02.004 PMCID: PMC5446048
Ongol MP, Niyonzima E, Gisanura I, Vasanthanakam H, Others. Effect of germination and fermentation on nutrients in corn flour. Pakistan Journal of Food Sciences [Internet]. Pakistani food business scientists and technicians; 2013; 23 (4): 183-188. Out there at: https://www.researchgate.net/profile/Niyonzima_Eugene2/publication/281554021_Effect_of_germination_and_fermentation_on_nutrients_in_maize_flour/links/55ed7ecd08ae21d099c759db.pdfmits  Carpenter KJ. Pellagra to maize ratio and low availability of niacin in cereals. Experientia Suppl [Internet]. Springer; 1983; 44: 197-222. Out there at: https://www.ncbi.nlm.nih.gov/pubmed/6357846 PMID: 6357846
Ghosh HP, Sarkar PK, Guha BC. Distribution of nicotinic acid sure type to pure supplies. J Nutr [Internet]. Oxford University Press; 1963 1 April [cited 2019 Feb 14] 79 (4): 451-453. Obtainable at: https://academic.oup.com/jn/article-abstract/79/4/451/4779288  Lerner F, Niere M, Ludwig A, Ziegler M. Structural and Useful Characterization of Human NAD Kinase. Biochem Biophys Res Commun [Internet]. 2001 October 19, 288 (1): 69-74. Out there at: http://dx.doi.org/10.1006/bbrc.2001.5735 PMID: 11594753
Sorci L, Cimadamore F, Scotti S, Petrelli R, Cappellacci L, Franchetti P, Orsomando G, Magni G. Preliminary kinetics of the rate of human NMN-adenyltransferases: substrate and metallic ion specificity, product inhibition, and multi-substrate analogues and effect of isozyme on NAD + biosynthesis. Biochemistry [Internet]. 2007 April 24, 46 (16): 4912-4922. Out there at: http://dx.doi.org/10.1021/bi6023379 PMID: 17402747
Heimburger DC. Medical manifestations of nutritional deficiencies and toxicity. In: Ross AC, editor. Trendy Vitamin for Health and Disease [Internet]. Out there at: https://chrismasterjohnphd.com/textbook  Kirkland JB. Niacin. In: Ross AC, editor. Trendy Vitamin for Health and Disease [Internet]. Obtainable at: https://chrismasterjohnphd.com/textbook  Niacin [Internet]. Linus Pauling Institute. 2014 [cited 2019 Feb 14]. Obtainable at: https://lpi.oregonstate.edu/mic/vitamins/niacin
Institute of Drugs, Standing Committee on Scientific Evaluation of Dietary Products, its Panel for Folate, Vitamins OB, Choline. Niacin [Internet]. Nationwide Academies Press (USA); 1998 [cited 2019 Feb 14]. Out there at: https://www.ncbi.nlm.nih.gov/books/NBK114304/  Institute of Drugs (US) Standing Committee on Scientific Evaluation of Nutritional Reference Values, its Folate Panel, Nutritional vitamins OB, Choline. Riboflavin [Internet]. National Academies Press (USA); 1998 [cited 2019 Feb 14]. Obtainable at: https://www.ncbi.nlm.nih.gov/books/NBK114322/  (perform (d, s, id)
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