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Your Comprehensive Guide to Lyme Disease

Lyme's disease explodes in america and around the globe. Although the CDC reviews that approximately 300,000 individuals are recognized with Lyme disease annually, this quantity might underestimate the true incidence of the illness due to defective diagnostic testing, misdiagnosis and underestimation. (1) Read more concerning the newest research in Lyme Disease and why it is pressing to increase awareness of this critical, quickly growing drawback.

Contents:

Long misunderstanding, Lyme illness is turning into more widespread and dangerous in the USA. Study extra about how this illness has spread, its signs and the way to check it. #functionalmedicine #chriskresser

What’s Lyme Disease?

Lyme disease is a multi-systemic infectious disease brought on by Borrelia burgdorferi, which is transmitted to people via contaminated mites. In the USA, two kinds of mites carry Lyme illness:

  • The japanese black stick (Ixodes scapularis), also called deer tip, transmits Lyme disease on the east coast and the Midwest
  • (Ixodes pacificus) transmits illness on the west coast

    • ), has not discovered Lyme disease, but transmits other harmful pathogens. Its speedy geographical enlargement into the Lyme endemic areas, including the south-east, east and central west, is a serious concern because the pathogens it transports can worsen the disease of people contaminated with Lyme. (2)

      What Causes Lyme Disease: Borrelia burgdorferi

      Borrelia burgdorferi is a spiral-like spiral-shaped bacterium related to syphilis but genetically more complicated micro organism. It’s the main reason for Lyme disease in North America, while Borrelia afzelii and Borrelia garinii, other members of the Borrelia complicated, are the first causes of Lyme an infection in Europe and Asia. (three) Lately, in North America, Borrelia miyamotoi, Borrelia mayonii and Borrelia hermsii have also been concerned in a big variety of instances of Lyme disease. (four, 5, 6, 7)

      How is Lyme Disease Sent?

      Borrelia bacteria require each an invertebrate vector – specifically, Ixodes ticks – and a vertebrate host to successfully full their life cycle. Timber are automobiles for sending Borrelia to "tank hosts," including mice and deer which are sometimes pathogenic.

      People who find themselves not Borrelia transfer automobiles serve a special but equally important position: they are a source of blood for mites, which plays an important position in the life cycle of Borrelia

      Throughout their three-year life cycle, mites undergo four levels of life: egg, caterpillar , nymph and grownup. Nymph Japanese Blacklegged Spikes have the very best price of an infection of Lyme illness, while the lice of solitary stars are aggressively attacking human hosts at all levels of life – adults, nymphs, and larvae. (8)

      The needles mediate Borrelia burgdorfer (and lots of different pathogens) in the course of the feeding course of:

      • First, a tick have to be discovered on the feeding website. When deposited on a human or animal, it attaches to the pores and skin and secrete a numbering substance that forestalls the host from feeling tick-rinsed.
      • Subsequent, the mite bites on the skin and feeds the feed tube and secures a cement-like substance that attaches it firmly to the skin throughout a blood meal.
      • Taurus slowly absorbs blood from the host for several days earlier than dropping and getting ready for a new life.

      If the tick accommodates some pathogens, infectious salivary organisms are transferred to the host in the course of the feeding process

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      History of Lyme disease

      Early studies of Lyme illness began to seem in america late within the 1960s and 1970s. Nevertheless, the medical group didn’t take any critical curiosity within the area till 1975, when a variety of individuals from the cities of Lyme and Previous Lyme Connecticut got here down with a wierd assortment of signs resembling fatigue, arthritis and neurological dysfunction. 19659002] Analysis by the scientific and medical communities ultimately led to the fact that all affected patients had skilled mite bites before the onset of the illness. Ultimately, the blacklegged cross was associated with the transmission of a new disease generally known as Lyme Disease. In 1981, Willy Burgdorfer, a Swiss American scientist, discovered the infectious explanation for Lyme disease, a persistent, genetically complicated spirochete that he referred to as Borrelia burgdorfer. (9)

      Lyme illness, thought-about a uncommon disease, has exploded in current many years. In accordance to the authors of the current Lyme article, “Lyme disease should be recognized as a virulent epidemic at least six times more common than HIV / AIDS.” (10)

      Lyme Disease

      Because the discovery of Lyme illness, it is filled with controversy . The overall medical group claims that Lyme disease is rare and simply treatable with a single cycle of antibiotics. Although the supporters of this claim embrace a number of prestigious medical organizations, together with CDC and the American Affiliation of Infectious Illnesses (IDSA), critical doubts have been expressed concerning the moral conduct of these teams within the Lyme Remedy Tips. (11)

      The International Lyme and Associated Illnesses Society (ILADS) is in direct opposition to CDC and IDSA, claiming that Lyme illness is a posh situation that always requires wider care than beneficial by typical tips. Despite ample proof that Lyme disease continues after remedy and that present diagnostic exams are inadequate, CDC and IDSA continue to oppose changing screening and remedy tips. Their perform (or lack of it) In entrance of Lyme, sufferers are nonetheless disadvantaged of the checks and treatments they need to enhance.

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      What are the signs of Lyme illness?

      bites man, it begins to transmit microbes which will embrace Borrelia burgdorferi. If the immune system reacts immediately to the arrival of B. burgdorfer, acute signs happen. If the immune system doesn’t shortly acknowledge the bacteria or if remedy fails in the course of the acute part, Lyme illness may cause persistent symptoms.

      Signs of Acute Lyme Disease

      Two of probably the most famous events suggesting the analysis of Lyme illness are current mite rash or erythema migrans, also referred to as 'bull-eye'.

      Erythema migraine is restricted for Lyme illness; it might have a analysis without medical checks. Nevertheless, few people with Lyme disease resemble past mite bites and up to 30% of instances haven’t any erythema migrans, severely limiting the medical utility of these two diagnostic features. (12)

      Other symptoms of acute Lyme illness are: Signs are often faulty to other illnesses akin to flu, delay the analysis of Lyme illness

      Symptoms of Continual Lyme Disease

      Lyme illness can develop into continual and cause physical and psychological impairment. Persistent Lyme disease is estimated to trigger a surprising 1.5 million individuals in america – far more than the 300,000 figure talked about by CDC. (13) The incidence of Persistent Lyme Disease is predicted to improve solely within the coming years, with almost two million individuals anticipated to be affected by 2020. (14)

      Some signs of continual Lyme illness overlap with acute symptoms, together with fatigue, joint pain, and sleep issues. Nevertheless, persistent Lyme disease may also cause more critical dysfunction in numerous physique techniques:

      • Neuropsychiatric problems comparable to melancholy, nervousness, headache, mind fog, temper swings, emotional lability, suicidal thoughts and cognitive dysfunction
      • aggression and violence. observed in some instances of Lyme disease and Lyme infections, particularly in Barton (15)
      • Alzheimer's disease, which manifests itself in a properly documented relationship between Lyme and neurodegenerative illnesses (16)
      • Immune issues and inflammation maintained by poor quality sleep
      • Neuropathy or Nervous system dysfunction, which may be brought on by inflammation of the nervous system in several elements of the body
      • Cardiovascular illnesses (17)
      • instances by which a pregnant lady has Lyme illness and is transmitted to her baby (18)

      How does Lyme Disease Turn into Persistent ? is a extra detailed question in more detail under, the brief answer is that continual Lyme develops if the illness is missed in its early levels and because of the complicated traits of Borrelia burgdorfer, which may forestall the immune system from being detected and remain

      ] How can Lyme illness trigger so many signs? Borrelia burgdorferi induces physiological dysfunction by several mechanisms:

      1. Borrelia causes irritation

      Borrelia burgdorferi evokes a profound systemic inflammatory response that relieves inflammatory cytokines that adversely affect tissues that change from heart to brain. The neuroinflammatory results of B. burgdorfer cause peripheral neuropathy and mind inflammation, main to melancholy, nervousness, cerebral fog and different neuropsychiatric signs. (19, 20)

      2. Borrelia Downregulates Immunity

      Borrelia burgdorferi lowers the host's immune perform, permitting it to remain undetected in the physique. (21) This subsequent suppression of the immune system makes the host more prone to opportunistic infections, which damages the physique.

      3. Borrelia Can Trigger Autoimmunity

      Continual Lyme illness also can trigger autoimmunity by way of cross-reactivity between B. burgdorferi antibodies and self-medication. This mechanism helps explain why Lyme disease has been linked to multiple sclerosis, rheumatoid arthritis and Alzheimer's disease. (22)

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      Lyme illness is turning into more prevalent and widespread

      In my previous article 5 myths and truths about continual lymphatic disease, I raised a number of widespread myths about Lyme disease – including the misunderstanding that it’s a rare suffering restricted to one To the USA

      Continuing these myths continues to hamper the timely analysis and effective remedy of the illness, causing numerous individuals to endure.

      In accordance to the CDC, there are over 300,000 new instances of Lyme illness in the USA annually. (23) Nevertheless, these figures are doubtless to be skewed. Understatements and inaccurate exams are probably to influence this – and the truth that many suspicious Lyme illnesses do not perform checks before beginning remedy. In 2018, the incidence of Lyme illness was estimated to be significantly greater than the 300,000 reported by the CDC, as an alternative of reaching almost one million individuals in america alone. By 2050, this quantity might rise to 55.7 million. (24)

      When patients dwelling outdoors the east coast typically notify their docs of Lyme illness, they have closed many occasions instantly, as most docs mistakenly consider that Lyme can only be executed on the east coast. Though Lyme illness was found on the east coast, it isn’t really limited to this area. In reality, it has been recognized in all 50 states and mites carrying it have been found in 43 of the 50 states.

      There are a number of reasons for the spread of Lyme disease in geographical distribution:

      • Individuals are creating increasingly pure areas and coming into contact with them
      • Climbing birds, deer and traveling individuals and pets (25)
      • mite life, which provides them extra time to infect animals and people (26, 27) Just as Lyme disease isn’t restricted to one space, it isn’t limited to rural or forest areas. Borrelia-bearing mites happen in comparable distributions in each urban and suburban areas. (28, 29)

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        Other Barrel Issues and Infections

        Although Borrelia burgdorferi has long been a focus of Lyme Disease Analysis, scientists discovered that single mite rinsing can send quite a few infectious organisms

        Puppies are B as well as to burgdorfer, dozens of microorganisms, together with other varieties of micro organism, parasites and viruses. Some organisms within the mites will not be pathogenic, however have an effect on the power of the mite to harbor and transport pathogens, which makes it virulent. (30, 31) Other insect organisms are pathogenic, trigger totally different signs and complicate the medical image:

        • Babesiosis: Babesia microti infection causes nervousness, sweating both day and night time, shortness of breath and heartbeat
        • Bartonella: Bartonella species the an infection causes sore throat, swollen glands, leg pain, stomach ache and ache in giant joints corresponding to shoulders and knees. Additionally it is related to neuropsychiatric issues reminiscent of nervousness, panic disorder, rage and sudden schizophrenia. (32, 33) Bartonella is widespread in cats and different domestic animals and veterinarians are at elevated danger of infection. (34, 35) Ehrlichiosis: Ehrlichiosis causes flu-like signs, together with dry cough, fatigue, muscle ache and low white blood cells. It also lowers platelets and raises liver enzymes. The incidence of Ehrlichia infection in the USA is growing, and generally, is happening in immunocompetent (non-immunocompromised) patients. (36)
        • Crime: Crime an infection is usually a nasty flu because it causes symptoms resembling fever, nausea and vomiting. In 50-85% of individuals it causes a purple spot rash in the palms. Like Ehrlichia, it also reduces white blood cells and platelets and raises AST and ALT. Rickettsia is believed to play a big but underestimated position in the pathogenesis of Lyme, which impacts the persistence of the illness. (37)
        • Mycoplasma: Mycoplasma pneumoniae stimulates B cells, causing autoimmune reactions and rheumatoid arthritis, fatigue and joint and muscle ache. The weakened immunity brought on by Borrelia burgdorfer makes the body more prone to Mycoplasma an infection. (38, 39)
        • Chlamydia infections: Chlamydia an infection causes arthritis, higher respiratory tract infections, and pneumonia and may contribute to the development of autoimmune illnesses. (40) Viruses: Injections have also been discovered to have a excessive viral density that transmits new forms of harmful viruses, such because the South Bay virus. (41)

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        Why Lyme Disease is so challenging to deal with

        In contrast to CDC and IDSA, we wish Lyme disease to be complicated and troublesome to treat. The entire elimination of B. burgdorfer spirochetes by antibiotics has not been achieved in any animal model ever tested. (42) Remedy of B. burgdorfer is troublesome due to the power of the bacterium to keep away from the immune system, alter its morphology and adapt to antibiotic remedies

        It weakens the immune system

        As I mentioned earlier, Borrelia is weakened by host immunity, together with adaptive immune response and complement system, a part of the immune system that improves the power of antibodies and phagocytes (micro organism and different small particles to break down cells) to remove harmful microbes. (43, 44) This not solely opens the physique to opportunistic infection, but in addition permits Borrelia to remain within the body. It modifications to avoid the immune system

        Borrelia also modifications its own morphology to avoid the immune system; it converts its particular spiral type right into a spherical cystic structure with no cell floor recognition proteins. (45) It additionally varieties other microorganisms, including the co-infectious brokers talked about above, to type a biofilm. (46, 47) Biofilm is an assembly of microorganisms embedded in a mucous extracellular matrix; when included into biofilm, the bacteria are resistant to antibiotic remedy. Within the case of Lyme illness with Borrelia biofilm remedy is much more troublesome

        It shortly adapts to antibiotics

        Borrelia burgdorferi shortly modifications the expression of genes in response to doxycycline, some of the generally prescription drugs of Lyme illness. antibiotic resistant phenotype. Doxycycline remedy of Borrelia contaminated mice causes Borrelia to regulate genes that facilitate bacterial dormancy and downregulate genes encoding cell surface proteins; these modifications outcome within the immune system stopping the "search" of the bacteria and permitting Borrelia's constant an infection. (48) B. burgdorferi has also proven resistance to amoxicillin and ceftriaxone, and remedy induces drug-tolerant "persister" cells. (49)

        A current research by Johns Hopkins University found a cocktail of three antibiotics that is helpful for purifying persistent Borrelia; nevertheless, it stays to be seen whether Borrelia can also be suitable for antibiotic mixtures. (50)

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        Transmission of Lyme between Individuals

        The switch of Lyme illness from individual to individual is controversial. While the CDC and IDSA recognize that Lyme disease could be transferred to the unborn lady to youngster by means of the placenta, they argue that "there is no observed adverse effects on the fetus when the mother receives appropriate antibiotic treatment." (51) [19659002ToisaaltayleinenlääketieteellinenyhteisöväittäävoimakkaastisitäajatustaettäLymevoidaanvälittääihmistenvälillämuidenreittienkutenseksuaalisenyhteydenkauttaUseattodisteetviittaavatkuitenkinsiihenettätämäuskoonvirheellinenBburgdorferiavoidaanviljellätartunnansaaneidenyksilöidenemättimennesteessäjasiemennesteessämikäviittaaseksuaalisensiirtymisenmahdollisuuteeninfektionmuotonaVaikkanämähavainnotovatedelleenspekulatiivisianeedellyttävätvarmastilisätutkimuksia(5253)JosLyme-taudintodetaanolevanseksuaalisestisiirrettäväätämävaikuttaisimerkittävästihoitoon

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        Testing Lyme Disease

        CDC and IDSA have been for many years in the analysis of Lyme disease. rikokeilustrategiaa. The primary degree is the ELISA (enzyme linked immunosorbent assay), which measures antibody levels towards Borrelia burgdorferi. The second degree, western blot, also checks antibodies to B. burgdorfer, however strikes one step further by saying reactivity to 10 totally different proteins discovered within the bacterium. Nevertheless, the two-tiered testing strategy poses several issues:

        1. The 2-tiered strategy has low sensitivity (the power to determine these with the illness) at 30-40% early in Lyme disease; for these of you who have no idea biostatistics, that is slightly obscure. In all levels of Lyme illness, together with typically devastating later levels, the sensitivity of the two-level algorithm rises to only 57.6%. (54, 55)
        2. Western blots don’t extract many naturally occurring strains of Borrelia that cause disease. Because western blots use antigens from cultured strains of Borrelia, not from medical samples, it does not decide up the various strains of Borrelia that naturally happen in our surroundings.
        3. The Western blot is susceptible to methodological points and subjectivity to interpretation. The weak variation of the western blot technique and the highly subjective nature of Western blot interpretation can lead to false negatives.

        It is clear that the present blood testing technique for Lyme disease is inadequate. But what checks must be used as an alternative? At the California Middle for Useful Drugs (CCFM), we’ve found that a mixture answer is most useful in diagnosing Lyme disease.

        Serological Testing

        As a first step, we advocate serological checks for Lyme disease. Serological checks embrace the ELISA, western blot and immunoblot, a brand new check that’s extra sensitive than the western blot and designed to be inserted. (56) Serological Lyme Checks could be performed by way of Stony Brook College, Quest, LabCorp, or IGeneX

        Molecular Testing

        If serological exams return to destructive, but Lyme disease is suspected, Lyme exams of next era molecules can be used for serological testing. complement the outcomes. ArminLabs EliSpot estimates the T cell immune response to Borrelia burgdorfer, reflecting the present activity of Lyme disease. The check turns unfavourable when B. burgdorferi is not lively, so it is helpful for monitoring the remedy

        International Lyme Diagnostics supplies a GLD check that checks for the presence of antibodies to the proteins on the exterior of B. burgdorfer, which extends the variety of species and strains might be detected. The range of the gadgets recognized within the check considerably reduces false destructive results.

        Ceres Nanoscience, another leading supplier of Lyme diagnostic solutions, supplies the Nanotrap Lyme Antigen Check. This check condenses Lyme antigens in the urine after which detects the antigens utilizing ELISA and western blot strategies.

        Importantly, we don’t advocate testing the Lyme check by PCR. Although PCR-based assays, akin to DNA Connexions, once appeared promising, they typically produce false positives and show low sensitivity. (57)

        Metabolomics: The Future of Lyme Disease Testing? Final however not least, there are promises in the area of metabolomics for future testing of Lyme disease. Metabolome experiments tested the biosignature of Lyme disease, which is characterized by particular proteins and other metabolites that either produce the bacterium immediately or in the physique in response to the bacterium. (58)

        Lyme disease is a "great imitator"

        The analysis of Lyme disease is further difficult by the fact that it imitates many different circumstances. In lots of instances, this leads to an incorrect analysis. Before Lyme Disease was recognized in Lyme, Connecticut, it was a misuse of juvenile arthritis. (59) Lyme has also been misdiagnosed as a number of sclerosis, neuropsychiatric issues and Alzheimer's illness. In some instances, untreated persistent Lyme illness can lead to these circumstances, so "incorrect diagnosis" may be partially right, regardless that it does not keep in mind the underlying explanation for the disease process. (60, 61, 62) Prime of page

        Prevention of Lyme Disease

        The only means to forestall Lyme disease is to avoid mite biting. Here's a fast take a look at how you can forestall ticks and what to do should you're biting. See "What to do with Bite Bite."

        Be Aware of the Outdoor

        Whenever you go climbing, walking, picnicking, or some other outside exercise, stay well-kept on the paths and keep away from tall grasses. Excessive grasses are one of the common habitats in ticks; when on the lookout for a number that feeds, animal or human, the mites rise to the outer ideas of the grass and wiggle their ft round waiting for an sudden passer by. (63) Keep away from operating a leaf litter or sitting on timber as mites also like to hand around in these locations.

        Use Insect Mechanism

        An insect repellent is crucial for small and other disease-carrying insects comparable to mosquitoes. You will have several options to an efficient repellant:

        • Lemon eucalyptus oil, which is natural, non-toxic and as effective as DEET to forestall peaks and mosquitoes (64, 65)
        • Permethrin, a synthetic insect repellent derived from chrysanthemums
        • ] DEET, in extreme mite exposure situations

        Usually, I like to recommend starting a protected various akin to lemon eucalyptus oil. Permethrin and DEET ought to be used with warning.

        Perform a daily “Tick Check”

        If you return house outdoor in cross-endetic areas, change your garments and place the used clothes within the dryer for 20 minutes – heat kills all of the mites which have ridden the experience. Next, do a radical evaluation of your youngster, companion and pet, and then somebody will examine you out. Be certain to look at your entire physique and verify in your youngsters before going to bed and within the evenings if they have played outdoors.

        The nymph fragments, which are the primary tick of Lyme disease, are the dimensions of the seed of the poppy and thus fairly troublesome to detect. You might need to use a magnifying glass. When you’ve got an iPhone or Android, you need to use the built-in magnifying glass tools, or it’s your decision to maintain a small magnifying glass at residence for this objective.

        Take away the hooked up flag safely

        When you have been toothed, it is rather necessary that you simply remove the mark immediately using the right removing method. I like to recommend utilizing a pair of TickEase tweezers with a effective tip specifically designed to remove sticks. Hold a pair of purse, mountaineering, automotive and home.

        So you’ll be able to safely remove it safely:

        1. Take the zero from the tweezers so that it’s as shut as potential to the skin
        2. carry it evenly, perpendicular to where it is hooked up
        3. Maintain the strain and look forward to the tick to launch

        Don’t squeeze the physique of the body, flip it on, burn it, or attempt some other house elements. This could improve the danger of infection because the tick can restore the stomach contents to the chew space.

        For extra info on removing logging, go to the Bay Space Lyme Basis's useful site for removing.

        for pathogens

        After eradicating the tick, place it in a plastic bag with a humid paper towel and reserve it for identification and pathogen testing. You’ll be able to attempt to determine the tick yourself through the use of assets akin to TickEncounter. Do you understand what sort of tick-bit you’ll be able to assist your physician determine whether or not to begin treating Lyme illness whereas ready for the results of the pathogen testing

        You’ve got a couple of choices tested for pathogens, corresponding to:

        • TickReport, which gives a complete pathogen research and a quick turnaround time of 72 hours, and [19659007] The Bay Area Lyme Foundation, which presents free – albeit slower check providers

        Pathogen testing can determine whether that bit has been borne by Borrelia burgdorfer. Understanding that eventually may give your physician the chance to start remedy immediately, which may help forestall continual problems of Lyme disease.

        In some instances, the physician might determine to initiate remedy before acquiring the outcomes of pathogen testing (or in instances where testing was not attainable). A number of elements go to such a selection, including your home of residence, the tick you selected and how long it was hooked up earlier than the removing. I recommend that you simply consult intently together with your physician concerning the right course of action.

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        Why a practical medical strategy is greatest for the remedy of persistent Lyme disease

        The normal medical strategy to treating Lyme disease could be very restricted, and although the place of antibiotics is in Lyme remedy, they don’t right the immune dysfunction, inflammation and other illness. brought on by metabolic issues. Useful drugs gives a totally totally different strategy that maintains the affected person's general physique well being and works to right the traits of persistent Lyme disease. Though each Lyme practical medical protocol is considerably totally different, you possibly can anticipate the next:

        • Anti-inflammatory weight loss plan and targeted dietary help: Proper vitamin helps to help wholesome immune perform and scale back Lyme-induced irritation, which supplies the inspiration
        • Antimicrobials: Each pharmaceutical and botanical antimicrobials have a place in the useful drugs strategy to Lyme illness.
        • Immune system and inflammatory Help: Both are crucial for the recovery of Lyme
        • Numerous compensation timber, that are mediated by ticks biting, might intrude with the intestinal microbiological, which set the stage bowel dysfunction, and systemic inflammation. As with food plan, help for intestinal well being ought to be the inspiration of any Lyme remedy protocol.
        • Muotin altistuminen: Monilla kroonista Lymen tautia sairastavilla potilailla on myös ollut homeen altistumista, joka vaarantaa edelleen heidän immuniteetinsa. Muotin altistuminen on useless yksi monista ympäristöystävällisistä sairauksista, joita Funktionaalinen lääketiede voi käsitellä Lymen taudissa.

        Sivun alkuun

        CCFM: ssä autamme ihmisiä eri puolilta Yhdysvaltoja toipumaan Lymen taudista ja muista sairaudet. Jos olet saanut pureman ja olet epäillyt, että sinulla voi olla Lymen tauti, on tärkeää, että saat tarkan diagnoosin mahdollisimman pian, jotta voit aloittaa hoidon. Klikkaa tästä saadaksesi lisätietoja klinikastamme.

        Lisää Lyme-taudin varoja:

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